3) About Me / Research Profile Page

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Founder & Research Profile

Dr Ewa Markiewicz
Founder, TAKMAL BioSystems

I study how biological systems restore order under stress—and why this control degrades with ageing. My work connects nuclear architecture, mechanotransduction, wound repair, and tissue organisation through a systems-level lens: living tissue as a far-from-equilibrium system governed by energy allocation, dissipation control, and regulatory coherence.

Research Focus

My research integrates:

Nuclear architecture and mechanotransduction (lamina, chromatin organisation, mechanical information flow)
Wound repair and scar formation as state transitions
Epithelial–mesenchymal self-organisation and regenerative patterning
Adipose–stromal coupling as a buffering and signalling controller
Neuro-endocrine modulation of local tissue thresholds (brain–skin axis)
Timing, synchrony, and control precision as determinants of outcome state

Across these domains, the unifying question is:
What governs the transition from adaptive repair to maladaptive ageing?

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From Research to Platform

TAKMAL BioSystems emerged from a consistent observation across systems: regeneration and ageing are not separate pathways—they are different regimes of the same dynamical system.

TAKMAL formalises this perspective through:

state-based modelling of tissue organisation
identification of control variables governing repair outcomes
biomarker architectures that reflect thermodynamic state
model-guided intervention strategies to stabilise regenerative regimes

(Platform implementation is proprietary; public content remains conceptual.)

Selected Themes (optional short section)

If you want a compact “signature” block on this page:

Signature idea: Regeneration depends less on total energy availability than on the coordinated control of energy flow—precision, coupling, timing, and structural order under stress.

Publications

A full list of peer-reviewed publications is available via:

ORCID: (link)
(Optional: add Google Scholar / institutional profile link if you use one.)

If you want a short “Selected Publications” list on-page, keep it to 5–8 items maximum and link out to ORCID for the full record.

Collaboration

I welcome discussion with research and translational teams interested in:

systems-level modelling of tissue repair
mechanistic understanding of regeneration failure
biomarker development grounded in organisational state
model-guided intervention design and testing

CTA: Contact

contact

From Regeneration to Senescence: Loss of Control in Ageing Tissue Systems