About TAKMAL BioSystems

My research integrates:

• Nuclear architecture and mechanotransduction (lamina, chromatin organisation, mechanical information flow)
• Wound repair and scar formation as state transitions
• Epithelial-mesenchymal self-organisation and regenerative patterning
• Adipose-stromal coupling as a buffering and signalling controller
• Neuro-endocrine modulation of local tissue thresholds (brain–skin axis)
• Timing, synchrony, and control precision as determinants of outcome state

Across these domains, the unifying question is: What governs the transition from adaptive repair to destabilised ageing states?

TAKMAL BioSystems emerged from a consistent observation across systems: regeneration and ageing are not separate pathways—they are different regimes of the same dynamical system.

TAKMAL formalises this perspective through:

• state-based modelling of tissue organisation
• identification of control variables governing repair outcomes
• biomarker architectures that reflect thermodynamic state
• model-guided intervention strategies to stabilise regenerative regimes

Academic Formation

I hold a PhD in Biochemistry from the Faculty of Biotechnology at the University of Wrocław, where my training combined molecular cell biology and phytochemical research. During this period, I undertook international research placements at the Max Planck Institute (Berlin) and the Jacques Monod Institute (Paris) through a CNRS fellowship.

Postdoctoral Research

At the Universities of Dundee and Durham, my research focused on human cell biology and degenerative ageing disorders associated with nuclear envelope dysfunction. This work established a long-standing interest in ageing as a systems-level failure of stress handling and structural integrity.

Independent Programme Leadership

As a recipient of a Medical Research Council (MRC) Career Development Award in Stem Cell Research at Durham University, I established and led an independent research programme examining stress-induced premature ageing and regenerative repair.

The work centred on skin and its appendages — including hair follicles and subcutaneous adipose tissue — investigating cellular senescence as a maladaptive response to unresolved stress and constrained regenerative capacity.

Research Leadership & Networks

I previously served as Head of Research at Hexis Lab (Newcastle upon Tyne, UK). My previous work has also involved collaboration across academic, clinical, governmental, and industry research networks, including:

• Euro-Laminopathies
• North East England Stem Cell Institute
• Columbia University Medical Center
• UK Health Security Agency

Current Focus

My current work integrates molecular, cellular, and systems biology with bioengineering and polypharmacology. The focus is on translating mechanistic insight into predictive, intervention-oriented models of ageing and regeneration.

This includes:

Fundamental integumentary biology

Biomarker discovery

State-based modelling of tissue organisation

Design and validation of next-generation topical interventions

Academia–industry collaboration in personalised health

A full list of publications is available via:

• ORCID

I welcome discussion with research and translational teams interested in:

• systems-level modelling of tissue repair
• mechanistic understanding of regeneration failure
• biomarker development grounded in organisational state
• model-guided intervention design and testing