About the Founder

My research integrates experimental biology, systems biology, and quantitative modelling across the following domains:

• Nuclear architecture, mechanotransduction, and chromatin organisation
• Wound repair, fibrosis, and regenerative state transitions
• Epithelial-mesenchymal self-organisation and tissue patterning
• Adipose-stromal regulation of tissue resilience
• Neuro-endocrine regulation of tissue adaptation (brain–skin axis)
• Timing, synchrony, and regulatory precision in regeneration and ageing

Across these domains, one question unifies the research: What governs biological state transitions from adaptive repair to ageing and degeneration?

TAKMAL BioSystems emerged from a consistent observation across biology: regeneration, ageing and disease are not separate processes — they represent different states of the same biological system.

TAKMAL translates this biological perspective into a quantitative modelling platform through:

• State-based modelling of tissue organisation
• Identification of biological control variables governing state transitions
• Biomarker architectures reflecting thermodynamic state
• Model-guided prediction and intervention design

The long-term vision is to use these models not only to predict biological behaviour, but to guide the design of experimental systems and regenerative interventions.

Academic Formation

I hold a PhD in Biochemistry from the Faculty of Biotechnology at the University of Wrocław, where my training combined molecular cell biology and phytochemical research. I also completed research fellowships at the Max Planck Institute (Berlin) and the Jacques Monod Institute (Paris) through CNRS.

Postdoctoral Research

At the Universities of Dundee and Durham, my research focused on human cell biology and degenerative ageing disorders associated with nuclear envelope dysfunction. This work established a long-standing interest in ageing as a systems-level failure of stress handling and structural integrity.

Independent Programme Leadership

As a recipient of a Medical Research Council (MRC) Career Development Award in Stem Cell Research at Durham University, I established and led an independent research programme examining stress-induced premature ageing and regenerative repair.

The work centred on skin and its appendages — including hair follicles and subcutaneous adipose tissue — investigating cellular senescence as a maladaptive response to unresolved stress and constrained regenerative capacity. This work was carried out at Columbia University Medical Center

Research Leadership & Networks

Most recently, I served as Head of Research at Hexis Lab (Newcastle upon Tyne, UK), leading research programmes spanning biomarker discovery, regenerative biology, and AI-enabled skin science. My previous work has also involved collaboration across academic, clinical, governmental, and industry research networks, including:

• Euro-Laminopathies
• North East England Stem Cell Institute
• Columbia University Medical Center
• UK Health Security Agency

Current Focus

My current work combines experimental biology with quantitative systems modelling to develop predictive models of tissue organisation, regeneration, ageing, and biological resilience.

This includes:

Biomarker discovery

Thermodynamic state modelling

Predictive systems modelling

In vitro model design

Translational collaboration

Research Highlights

• 25+ years in experimental biology
• 40+ scientific publications
• MRC-funded independent programme
• International research (Germany, France, Poland, UK, USA)

• Academic and industrial leadership
• Founder, TAKMAL BioSystems

A full list of publications is available via:

• ORCID
• Google Scholar

I welcome collaborations with academic, biotechnology, pharmaceutical, and translational research teams interested in:

• Systems-level modelling of regeneration and tissue repair
• Mechanisms governing regenerative failure and ageing
• Biomarker discovery for biological state estimation
• Model-guided experimental design and therapeutic development